Brain Vascular Heterogeneity

In the vertebrate brain, vascular endothelial cells exhibit heterogeneous structural and functional properties that are critical to mirror the brain’s diverse functions.  Two striking examples of this heterogeneity are the vECs that form the semi-permeable blood-brain barrier (BBB) and those that develop highly permeable fenestral pores (fenestrae). We are very interested in understanding how these heterogeneous brain vascular networks are generated during neural development.  Our current focus is to define the cellular and molecular basis of fenestrated brain vascular development using the choroid plexus as a model system.

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